丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂ALS偺栻暔椕朄偺尰忬

丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂T.Kihira丂丂2003/3/6

丂丂丂丂丂丂丂丂丂丂丂丂丂ALS偺尨場偑柧傜偐偱側偄尰忬偱偼丄岠壥揑側栻暔帯椕偼婜懸偱偒側偄偲峫偊傜傟傞偑丄
丂丂丂丂丂丂丂 丂丂丂丂昦場壖愢偵婎偯偄偨栻暔帯椕偺壜擻惈偵偮偄偰丄尰帪揰偱偺抦尒傪曬崘偡傞丅


丂丂 丂丂丂丂丂丂丂丂峈僌儖僞儈儞巁栻暔

丂丂丂丂丂丂丂丂丂丂丂丂丂嫽暠惈恄宱嵶朎巰偺壖愢偐傜丄僌儖僞儈儞巁漢峈栻riluzole乮rilutek乯偑巊梡偝傟偰偄傞丅
丂丂丂丂丂丂丂丂丂丂丂 栻嵻搳梌偺弶婜偁傞偄偼幘姵弶婜偵搳梌偡傞偲丄墑柦岠壥偑帵偝傟偨丅
丂丂丂丂丂丂丂丂丂丂丂丂丂gabapentin偼丄僌儖僞儈儞巁宯偺峈偰傫偐傫栻偲偟偰奐敪偝傟丄傾儊儕僇偱偼擣壜偝傟偰偄
丂丂丂丂丂丂丂丂丂丂丂 傞偑丄Miller傜偵傛傝ALS偺姵幰偵偍偗傞忋巿扙椡傪抶墑偝偣傞壜擻惈偑曬崘偝傟偨丅戝恖偱
丂丂丂丂丂丂丂丂丂丂丂 900mg/day暘3乮偁傞偄偼300mg/day暘3乯偐傜巒傔丄巄帪憹検偡傞丅1擔憤検1800乣2400mg
丂丂丂丂丂丂丂丂丂丂丂 傑偱丅岠壥偼柧傜偐偱側偄偲偺寢壥傕偁傞丅暃嶌梡偼寫懹姶丄旀楯姶丄栚峥摍偱偁傞丅偦偺懠丄
丂丂丂丂丂丂丂丂丂丂丂 懁嵔宆傾儈僲巁乮僶儕儞丄儘僀僔儞丄僀僜儘僀僔儞乯偼恄宱宯撪偱僌儖僞儈儞巁偺扙悈慺壔峺慺傪
丂丂丂丂丂丂丂丂丂丂丂 妶惈壔偟丄僌儖僞儈儞巁偺暘夝傪懀恑偡傞偲峫偊傜傟偨丅椪彴帋尡偺寢壥丄岠壥偼斲掕揑丅
丂丂丂丂丂丂丂丂丂丂丂丂丂怴偟偄峈偗偄傟傫栻偱偁傞丄topiramate偑anti-excitotoxic岠壥傪桳偡傞偲峫偊傜傟偨丅恄宱
丂丂丂丂丂丂丂丂丂丂丂 嵶朎偐傜偺glutamate曻弌傪尭彮偝偣丄glutamate recepter乮AMPA/kinate recepter乯傪僽儘僢僋
丂丂丂丂丂丂丂丂丂丂丂 偡傞偲偝傟傞丅愐悜婍姱攟梴宯傪梡偄丄glutamate transport傪栻棟妛揑偵慾奞偡傞幚尡宯偱
丂丂丂丂丂丂丂丂丂丂丂 topiramate偺岠壥傪専摙偟偨丅topiramate傪3廡娫偺搳梌屻丄塣摦恄宱曄惈偺桳堄側尭彮傪
丂丂丂丂丂丂丂丂丂丂丂 擣傔偨丅偟偐偟側偑傜丄G93A mice偱偼岠壥偑側偐偭偨乮Maragakis NJ, Rothstein JD.
丂丂丂丂丂丂丂丂丂丂丂 Neurosci Lett, 2003, 338, 107-10乯丅
丂丂丂丂丂丂丂丂丂丂丂丂丂捔奝栻偲偟偰抦傜傟傞dextromethorphane偼丄僌儖僞儈儞巁偺NMDA傪夘偡傞庴梕懱傪慾奞
丂丂丂丂丂丂丂丂丂丂丂 偡傞栻嵻偲峫偊傜傟丄14椺偺ALS姵幰偵150mg/day偁傞偄偼placebo偺椪彴帋尡偑側偝傟丄12
丂丂丂丂丂丂丂丂丂丂丂 廡娫屻偺昡壙偑側偝傟偨丅Fig.1嶲徠丄昡壙偼Norris score, Plaitakis et al偺bulbar and spinal
丂丂丂丂丂丂丂丂丂丂丂 score傪巊梡丅搳梌孮偲placebo孮偱忋婰score偵桳堄嵎傪擣傔側偐偭偨丅偝傜偵300mg/day
丂丂丂丂丂丂丂丂丂丂丂 6儠寧娫偺open trial偑懕峴偝傟偨偑丄relative number of axons, compound muscle action
丂丂丂丂丂丂丂丂丂丂丂 potentials, 媦傃椪彴徢忬偵岠壥偼擣傔側偐偭偨乮嘆Askmark H, et al., J Neurol Neurosurg
丂丂丂丂丂丂丂丂丂丂丂 Psychiatry, 1993, 56, 197-200乯丅嵟嬤丄嵞搙ALS姵幰偵dextromethorphan 150mg/day傪
丂丂丂丂丂丂丂丂丂丂丂 randamized, double-blind, placebo-controlled study傪峴偭偨曬崘偱偼丄45椺偺搊榐偑偁傝丄
丂丂丂丂丂丂丂 丂丂丂丂12儠寧屻偺昡壙偱偼丄placebo孮偱偼15椺乮65%乯丄dextromethorphan孮偱偼12椺乮55%乯偺惗
丂丂丂丂丂丂丂丂丂丂丂 懚偑偁傝丄攛婡擻偲functional disability偺昡壙偱偼椉孮偲傕摨條偺decline偱偁偭偨偲偺曬崘偑
丂丂丂丂丂丂丂丂丂丂丂 側偝傟偰偄傞乮Gredal O. et al. Acta Neurol Scand, 1997, 96, 8-13乯丅


丂丂丂丂丂丂丂丂丂丂丂 峈梀棧婎栻暔

丂丂丂丂丂丂丂丂丂丂丂丂丂Ca僀僆儞偺恄宱嵶朎撪偵偍偗傞娚徴抈敀偲偟偰丄僇儖價儞僨傿儞丄僷儖儃傾儖僽儈儞偑抦傜傟
丂丂丂丂丂丂丂丂丂丂丂 傞丅嵶朎撪Ca僀僆儞偑夁忚偵憹壛偡傞偲丄梀棧婎嶻惗峺慺偑妶惈壔偝傟丄嵶朎偺曄惈巰柵傊
丂丂丂丂丂丂丂丂丂丂丂 偲嵶朎偺戙幱偑揮姺偡傞丅phospholipase, xanthine oxidase偼superoxide傪庡懱偲偟偨梀棧婎
丂丂丂丂丂丂丂丂丂丂丂 嶻惗傪懀偟丄nitric oxide synthase乮NOS乯偼NO側偳偺梀棧婎傪嶻惗偡傞丅梀棧婎偺憹壛偵懳偡
丂丂丂丂丂丂丂丂丂丂丂 傞帯椕栻偲偟偰Vitamin C, E偑抦傜傟傞偑丄帯椕岠壥偼側偄偲偝傟傞丅N-acetylcysteine偼梀棧
丂丂丂丂丂丂丂丂丂丂丂 婎惔憒栻偱偁傞偑丄ALS偺戞2憡椪彴帋尡偱堦掕偺岠壥偑帵嵈偝傟偨丅Selegiline偼梀棧婎惔
丂丂丂丂丂丂丂丂丂丂丂 憒栻偲偟偰抦傜傟傞偑丄ALS偺椪彴帋尡偱偼岠壥側偟丅
丂丂丂丂丂丂丂丂丂丂丂丂丂暘巕岺妛揑偵嶌惉偝傟偨僸僩SOD1偺intrathecal pump偵傛傞愐悜悜峯撪搳梌偼壠懓惈ALS
丂丂丂丂丂丂丂丂丂丂丂 偺2椺偲旕壠懓惈ALS14椺偱6儠寧娫偺帩懕搳梌偑側偝傟偨丅埨慡惈偵偼栤戣側偄偑丄帯椕岠
丂丂丂丂丂丂丂丂丂丂丂 壥側偟丅


丂丂丂丂丂丂丂丂丂丂丂 傾億僩乕僔僗梷惂栻

丂丂丂丂丂丂丂丂丂丂丂丂丂anti-apoptotoc傑偨偼neurorescuing agents偲屇偽傟傞丅
丂丂丂丂丂丂丂丂丂丂丂丂丂creatine偼惓忢僸僩丄恄宱嬝幘姵姵幰偵偍偄偰嬝椡傪憹壛偡傞偙偲偑曬崘偝傟偰偄傞丅28椺
丂丂丂丂丂丂丂丂丂丂丂 偺ALS姵幰偵塣摦悑峴偲嵟戝悘堄摍広惈嬝廂弅乮MVIC乯傪巜昗偵丄creatine 20g/day 7擔娫
丂丂丂丂丂丂丂丂丂丂丂 暈梡屻丄3g/day 3-6儠寧宲懕暈梡偝偣偨丅7擔屻偺MVIC偼knee extensors偱70%丄elbor flexos
丂丂丂丂丂丂丂丂丂丂丂 偱53%偺姵幰偵偍偄偰憹壛偟偨丅Fatigue test偱傕32-39%偺姵幰偱夵慞傪帵偟偨丅6儠寧屻偺宱
丂丂丂丂丂丂丂丂丂丂丂 夁娤嶡偱偼丄偙傟傜偺嬝椡昡壙偼彊乆偵掅壓偟偨乮Mazzini L, et al., J Neurol Sci 2001, 191,
丂丂丂丂丂丂丂丂丂丂丂 139-44.乯丅
丂丂丂丂丂丂丂丂丂丂丂 丂 ALS徢椺偺堦晹偱丄嬝mitochondria屇媧嵔峺慺寚懝傪帵偡傕偺偑偁傝丄mitochondrial DNA
丂丂丂丂丂丂丂丂丂丂丂 depletion偵傛傞偲峫偊傜傟偰偄傞丅偟偐偟丄塣摦旂幙偱偺儈僩僐儞僪儕傾堎忢偵偮偄偰偼抦傜傟偰
丂丂丂丂丂丂丂丂丂丂丂 偄側偄丅Vielhaber傜偼丄ALS戝擼塣摦旂幙偵偍偄偰儈僩僐儞僪儕傾婡擻堎忢偺懚嵼偺壜擻惈偲丄
丂丂丂丂丂丂丂丂丂丂丂 偝傜偵宱岥搳梌creatine偺岠壥傪専摙偟偨丅creatine偼儈僩僐儞僪儕傾巁壔揑儕儞巁壔傪巋寖偟丄
丂丂丂丂丂丂丂丂丂丂丂 晹暘揑側屇媧嵔梷惂偵岠壥偑偁傞偲峫偊傜傟傞丅creatine偼擼撪偵BBB傪墇偊偰怤擖偟丄掅壓偟
丂丂丂丂丂丂丂丂丂丂丂 偨N-acetylaspartate乮NAA乯儗儀儖傪憹壛偝偣傞偲峫偊傜傟傞丅creatine搳梌屻偺塣摦旂幙偱偺
丂丂丂丂丂丂丂丂丂丂丂 N-acetylaspartate乮NAA乯/creatine乮Cr乮t乯乯媦傃NAA/choline斾傪乮1乯H NMR-visible metabolites
丂丂丂丂丂丂丂丂丂丂丂 偲偟偰娤嶡偟偨丅ALS15椺偱偼motor cortex偺NAA/Cr乮t乯戙幱暔斾偑惓忢15椺偵斾偟掅壓偟丄
丂丂丂丂丂丂丂丂丂丂丂 ALS偵偍偗傞NAA偺掅壓偑帵偝傟偨丅creatine搳梌屻偼丄惓忢偱偼NAA/Cr乮t乯丄NAA/Choline
丂丂丂丂丂丂丂丂丂丂丂 戙幱暔斾偑掅壓偡傞偑丄ALS偱偼曄壔偑側偄丅creatine曗廩椕朄偼ALS偺motor cortex偵偍偄偰
丂丂丂丂丂丂丂丂丂丂丂 掅壓偟偨NAA偲choline傪憹壛偝偣傞岠壥偑偁傞偲曬崘偝傟偨乮Vielhaber S, et al, Exp Neurol, 2001,
丂丂丂丂丂丂丂丂丂丂丂 172, 377-82乯丅
丂丂丂丂丂丂丂丂丂丂丂丂丂偟偐偟丄Drory偺曬崘偱偼creatine搳梌偼柍岠偲偝傟偨丅懄偪丄恑峴婜偺ALS姵幰14椺偵
丂丂丂丂丂丂丂丂丂丂丂 creatine傪5g/day暈栻偝偣丄屇媧婡擻forced vital capacity乮FVC乯丄forced expiratory vorume
丂丂丂丂丂丂丂丂丂丂丂 乮FEV乮1乯乯丄peak expiratory flow rate乮PEF乯丄maximum voluntary ventilation乮MVV乯傪娤嶡偟偨丅
丂丂丂丂丂丂丂丂丂丂丂 搳梌屻1丄2丄3媦傃4儠寧屻偺偙傟傜偺僨乕僞偱偼夵慞傪擣傔側偐偭偨乮Drory VE, Amyotrophic
丂丂丂丂丂丂丂丂丂丂丂 lateral sclerosis other Motor Neuron Disord, 2002, 3, 43-6乯丅
丂丂丂丂丂丂丂丂丂丂丂丂丂嵟嬤丄Zhang W.傜偼丄SOD1 tg mice偵偍偄偰creatine偲minocycline偺combinatorial therapeutics
丂丂丂丂丂丂丂丂丂丂丂 偑neuroprotective側岠壥偑偁傞偲曬崘偟偨丅偄偢傟傕宱岥搳梌偱BBB傪墇偊丄埨慡惈傕帵偝傟偰
丂丂丂丂丂丂丂丂丂丂丂 偄傞偨傔丄椪彴帋尡偺弨旛偑恑傫偱偄傞丅Tg mouse乮G93A乯偵2%creatine傪娷傓帞椏傪3廡椷
丂丂丂丂丂丂丂丂丂丂丂 mouse偵搳梌丄minocycline 22mg/kg bw/day傪intraperitoneally偵搳梌乮Zhang W., Ann Neurol.
丂丂丂丂丂丂丂丂丂丂丂 2003, 53, 267-70乯丅
丂丂丂丂丂丂丂丂丂丂丂丂丂Neurorescuing/antiapoptotic岠壥偑婜懸偝傟傞栻嵻偲偟偰丄乮-乯-deprenyl偑抦傜傟偰偄傞丅
丂丂丂丂丂丂丂丂丂丂丂 僷乕僉儞僜儞昦偱偼MAO-B慾奞栻偲偟偰婛偵巊梡偝傟偰偄傞偑丄忋婰偺岠壥偼偦傟偲偼暿屄偵
丂丂丂丂丂丂丂丂丂丂丂 峫偊傜傟偰偄傞丅乮-乯-desmethyldeprenyl妶惈傪桳偡傞偲峫偊傜傟傞偑丄戙幱偝傟偰amphetamine
丂丂丂丂丂丂丂丂丂丂丂 methanphetamine偵側傝丄恄宱曐岇嶌梡傪傕偮丅CGP3466乮dibenzo[b,f]oxepin-10-ylmethyl-
丂丂丂丂丂丂丂丂丂丂丂 methyl-prop-2-ynyl-amine乯偼峔憿揑偵乮-乯-deprenyl偵桼棃偟丄幚幙揑偵偼MAO-B, MAO-A
丂丂丂丂丂丂丂丂丂丂丂 慾奞嶌梡傪傕偨側偄偟丄amphetamines傊戙幱偝傟側偄丅Glyceraldehyde-3-phosphate dehydrogenase
丂丂丂丂丂丂丂丂丂丂丂 側偳夝摐宯峺慺偵寢崌偟丄apoptosis傪慾奞偟丄恄宱曐岇嶌梡傪敪婗偡傞丅乮-乯-deprenyl偺岠壥偺
丂丂丂丂丂丂丂丂丂丂丂 100攞偺嶌梡傪傕偮偲偝傟傞丅PC12攟梴嵶朎偱偺塰梴場巕屚妷偵傛傞apoptosis傪桳堄偵尭彮偝偣丄
丂丂丂丂丂丂丂丂丂丂丂 彫擼梓棻嵶朎偺cytosine arabinoside搳梌偵傛傞apoptosis偺梷惂丄儔僢僩攖拞擼dopaminergic嵶朎
丂丂丂丂丂丂丂丂丂丂丂 偺MPP+朶業偵傛傞嵶朎巰偺梷惂岠壥丄僸僩neurobrastoma cell偵rotenone朶業偵傛傞嵶朎巰梷惂
丂丂丂丂丂丂丂丂丂丂丂 岠壥側偳偑抦傜傟偰偄傞丅In vivo偺摦暔幚尡偱偼丄0.0003-0.1mg/kg p.o.ro s.c.搳梌偱儔僢僩婄柺
丂丂丂丂丂丂丂丂丂丂丂 恄宱愗抐屻偺嵶朎懱偺曐岇岠壥丄堦夁惈嫊寣屻偺rat CA1neurons偺曐岇丄MPTT搳梌儔僢僩偱偺
丂丂丂丂丂丂丂丂丂丂丂 崟幙dopaminergic cell偺嵶朎巰梷惂岠壥偑擣傔傜傟傞丅ALS model-mouse乮progressive motor
丂丂丂丂丂丂丂丂丂丂丂 neuronopathy乯偱傕懱廳偺曐帩丄塣摦婡擻偺夵慞丄惗懚婜娫墑挿岠壥偑帵偝傟偰偄傞丅昦棟専嶕
丂丂丂丂丂丂丂丂丂丂丂 偱傕儈僩僐儞僪儕傾偺曐岇偲塣摦恄宱嵶朎偺巆懚偑帵偝傟偰偄傞乮Waldmeier PC, et al. J neural
丂丂丂丂丂丂丂丂丂丂丂 Transm Suppl, 2000, 乮60乯, 197-214, Novartis.com乯丅
丂丂丂丂丂丂丂丂丂丂丂丂丂僇僗僷乕僛梷惂偑ALS偵岠壥偑偁傞偐傕偟傟側偄偲偺壖愢偐傜丄zVAD-fmk傪SOD1乮G93A乯mice
丂丂丂丂丂丂丂丂丂丂丂 偵擼幒撪搳梌偟丄敪徢抶墑偲惗懚棪傪擣傔偨曬崘偑側偝傟偰偄傞丅偝傜偵zVAD-fmk偼caspase-1
丂丂丂丂丂丂丂丂丂丂丂 妶惈偺梷惂偺傒側傜偢caspase-1, -3 mRNA up-regulation傪傕梷惂偟偨乮Li M, et al. Science 2000,
丂丂丂丂丂丂丂丂丂丂丂 288, 335-9乯丅偨偩偟丄傾億僩乕僔僗僇僗働乕僪偺嵟廔幚峴抈敀偱偁傞caspase-3敪尰傪柶塽慻怐妛
丂丂丂丂丂丂丂丂丂丂丂 揑偵ALS愐悜偱専摙偟偨曬崘偱偼丄偦偺敪尰憹嫮傪擣傔偰偄側偄乮拞栰崱帯丄恄宱曄惈幘姵偵娭
丂丂丂丂丂丂丂丂丂丂丂 偡傞挷嵏尋媶丄2002乯丅


丂丂丂丂丂丂丂丂丂丂丂 峈墛徢嶌梡栻

丂丂丂丂丂丂丂丂丂丂丂丂丂ALS偺昦場壖愢偲偟偰丄glutamate-mediated excitotoxicity偲free radicals偺拁愊偵傛傞oxidative
丂丂丂丂丂丂丂丂丂丂丂 damage偑憐掕偝傟傞丅Cyclooxygenase-2乮COX-2乯偼prosstaglandins嶻惗傪捠偟偰astrocyte偐傜
丂丂丂丂丂丂丂丂丂丂丂 偺僌儖僞儈儞巁曻弌偺僩儕僈乕偲側傝丄偝傜偵妶惈峺慺傪嶻惗偡傞丅Drachman傜偼ALS偺愐悜婍姱
丂丂丂丂丂丂丂丂丂丂丂 攟梴儌僨儖偵偍偄偰COX-2慾奞栻SC236傪揔墳偟丄塣摦恄宱扙棊傪桳堄偵梷惂偱偒傞偙偲傪曬崘
丂丂丂丂丂丂丂丂丂丂丂 偟偨乮Drachman DB, Rothstein JD, Ann Neurol, 2000, 48, 792-5乯丅偝傜偵tg mouse乮G93A乯偵
丂丂丂丂丂丂丂丂丂丂丂 cyclooxygenase 2 inhibitor乮celecoxib乯傪mice帞椏偵崿擖偟乮1500 parts per million乯丄愐悜偺
丂丂丂丂丂丂丂丂丂丂丂 prostaglandin E2偺娷検傪應掕丄搳梌孮偱桳堄側E2嶻惗梷惂傪擣傔偨乮Fig 1乯丅偝傜偵丄塣摦婡擻
丂丂丂丂丂丂丂丂丂丂丂 扙棊偺敪徢傪抶墑偟丄惗懚婜娫偺墑挿乮25%乯乮Fig 2乯偲扙椡丒懱廳尭彮敪徢偺抶墑傪擣傔偨丅
丂丂丂丂丂丂丂丂丂丂丂 昦棟専嶕偱傕celecoxib搳梌儅僂僗愐悜偱偼愐悜恄宱嵶朎偺曐懚偲astrocyte偺憹惗梷惂丄
丂丂丂丂丂丂丂丂丂丂丂 microglia妶惈壔偺梷惂偑擣傔傜傟偨乮Drachman DB, et al. Ann Neurol, 2002, 52, 771-8乯丅
丂丂丂丂丂丂丂丂丂丂丂丂丂ALS姵幰偵偍偄偰偼丄proinflammatrory enzyme偲偟偰偺cyclooxygenase乮COX乯-2偑姵幰擼丒
丂丂丂丂丂丂丂丂丂丂丂 愐悜丄媦傃ALS model mice偱憹壛偟偰偄傞偲偺曬崘偑偝傟偨乮McGeer PL et al., Muscle Nerve,
丂丂丂丂丂丂丂丂丂丂丂 2002, 26, 459-470乯丅COX-2偼墛徢僇僗働乕僪偺峺慺偱偁傝丄傑偨惓忢偺恄宱妶惈傪桳偡傞峺慺
丂丂丂丂丂丂丂丂丂丂丂 偱偁傞偙偲偐傜丄ALS帯椕栻偲偟偰偺壜擻惈偑専摙偝傟偨丅梊杊揑偵COX-2慾奞栻nimesulide傪
丂丂丂丂丂丂丂丂丂丂丂 SOD1 mice, G93A偵偍偄偰帞椏偵崿擖搳梌偟偨幚尡偱偼丄恄宱徢忬敪徢偺抶墑偲愐悜偱偺
丂丂丂丂丂丂丂丂丂丂丂 prostaglandin E2偺憹壛梷惂傪擣傔偨乮Pompl PN, et al., FASEB J, 2003, Feb 5乯丅Rothstein傜偺
丂丂丂丂丂丂丂丂丂丂丂 僌儖乕僾傕丄tg mice傪巊梡偟COX-2慾奞栻偺桳梡惈傪専摙偟偨丅椪彴帋尡偲偟偰偼擔杮偱偼
丂丂丂丂丂丂丂丂丂丂丂 儊儘僉僔僇儉偲偟偰婛偵彜昳壔偝傟偰偄傞偑丄ALS偵懳偡傞擇廳栍専朄偵傛傞帯尡偺寁夋偑恑峴
丂丂丂丂丂丂丂丂丂丂丂 拞偱偁傞丅Definite偁傞偄偼probable ALS姵幰傪懳徾偲偟2孮偵暘偗丄1孮偵偼riluzole 100mg/day
丂丂丂丂丂丂丂丂丂丂丂 + 僾儔僙儃丄2孮偵偼riluzole 100mg/day + 儊儘僉僔僇儉 10mg/day暈梡偲偟丄帯尡婜娫6儠寧丄
丂丂丂丂丂丂丂丂丂丂丂 Apple偺ALS僗僐傾偲ALSQOL-11丄MUNE偱昡壙偡傞乮峳嶈傜乯丅


丂丂丂丂丂丂丂丂丂丂丂 恄宱塰梴場巕

丂丂丂丂丂丂丂丂丂丂丂丂丂恄宱塰梴場巕偼丄惗懱偵嬌旝検懚嵼偡傞抈敀場巕偱丄恄宱嵶朎偺敪惗丄憹怋丄暘壔丄嵞惗夁掱
丂丂丂丂丂丂丂丂丂丂丂 傪挷愡偟偰偄傞偲峫偊傜傟偰偄傞丅Anand傜偼ALS愐悜慜妏偵偍偄偰ciliary neurotrophic factor
丂丂丂丂丂丂丂丂丂丂丂 乮CNTF乯偺尭彮傪帵偟偨丅CNTF丄BDNF丄GDNF摍偺椪彴帋尡偱偼1丄2憡帋尡偱暃嶌梡偺掱搙偼
丂丂丂丂丂丂丂丂丂丂丂 寉搙偲偝傟偨偑丄3憡帋尡偱嬝椡丒攛妶検偵夵慞傪擣傔側偐偭偨丅CNTF偱偼戞3憡偱偺暃嶌梡偑
丂丂丂丂丂丂丂丂丂丂丂 嫮偔丄扙椡丒攛妶検掅壓丒怘梸晄怳丒懱廳尭彮偑傒傜傟偨丅BDNF偱偼旂壓拲幩偱搳梌偝傟丄BBB傪
丂丂丂丂丂丂丂丂丂丂丂 捠夁偡傞偙偲側偔NMJ傛傝庢傝崬傑傟傞丅嵟嬤偱偼悜峯撪搳梌偑側偝傟丄埨慡惈偼帵偝傟偨丅悜峯撪
丂丂丂丂丂丂丂丂丂丂丂 搳梌偺暃嶌梡偲偟偰丄堦夁惈偺巐巿杻醿傪擣傔傞丅岠壥偼CNTF丄BDNF丄GDNF偲傕椪彴徢忬夵慞
丂丂丂丂丂丂丂丂丂丂丂 傪傕偨傜偝側偐偭偨丅

丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂丂